The fix requires you edit registry settings. I take no responsibility if this actually ruins your system... that said, if you can't use USB devices, your Vista system is in a bad state either way because everything these days tends to need USB.
As will always be the case, I have tested this solution. It works and I would rate is as an easy fix to apply.
Tested: Windows Vista Home Premium.
Original Source: Microsoft TechNet Post
Thanks to: NareshV
VISTA USB DEVICE DRIVER FIX.
- Click the Start icon (Start Menu).
- Either type "regedit" (without the quotes); or
Click Run and type "regedit", then Click OK.
- In Registry Editor, navigate to:
HKEY_LOCAL_MACHINE\
Software\
Microsoft\
Windows\
CurrentVersion
TIP: You will know you are in the right place because the Status Bar gives your location. - In the right hand Registry Editor pane (click on picture above for close up), double-click DevicePath.
- In the Edit String window. Add a semicolon ";" to the end of the existing details. Then add this path
%SystemRoot%\System32
The full details in the edit window should now look like this:
%SystemRoot%\inf;%SystemRoot%\System32
IMPORTANT NOTE: If there is ANYTHING else there, DO NOT REMOVE IT! Just add %SystemRoot%\System32 only. If you did delete something by accident, just click Cancel and repeat from Step 4 again. - Click OK to save the changes.
- Exit Registry Editor.
NOTE: Vista User Account Control may ask for permission to continue. If so, click Continue.
This will load Registry Editor.

4 comments:
AWESOME POST .... GREAT ONE
Crud. I got an "Error Editing Value Cannot edit DevicePath: error editing the value's new contents." I am still seriously stuck!
TJP
FIX did not work for me. I tried to uninstall and then plug it back in, I tried a re-start. Nothing worked. I have a new 8GB PNY (vista ready upgrade) flash drive.
Just a tip for those having trouble. You MUST have administrator privileges on the PC you're trying to fix. Also, it seems that this problem is fixed automatically by Vista SP1.
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